Abstract |
Riboflavin deficiency in rats resulted in a reduction in the transfer of 59Fe from an intragastric dose to plasma compared to age-matched or weight-matched controls. The uptake of iron by brush-border membrane vesicles made from intestinal mucosa of riboflavin-deficient rats was much less than identically-prepared vesicles from control groups. Although the mucosal content of 59Fe was smaller in riboflavin-deficient rats thirty minutes after dosing, the relative distribution of 59Fe between the mucosal iron-binding proteins, ferritin and transferrin, was not changed compared to the control groups. These studies suggest that the impairment in iron absorption in riboflavin deficiency is primarily the result of a reduced uptake of iron into the mucosal cell and not a redistribution of iron between iron-binding proteins inside the mucosal cell.
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Authors | B F Butler, R W Topham |
Journal | Biochemistry and molecular biology international
(Biochem Mol Biol Int)
Vol. 30
Issue 1
Pg. 53-61
(May 1993)
ISSN: 1039-9712 [Print] England |
PMID | 8358336
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Hemoglobins
- Transferrin
- Ferritins
- Iron
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Topics |
- Animals
- Body Weight
- Ferritins
(metabolism)
- Hemoglobins
(analysis)
- Intestinal Mucosa
(metabolism)
- Iron
(blood, metabolism)
- Male
- Microvilli
(metabolism)
- Organ Size
- Rats
- Riboflavin Deficiency
(metabolism)
- Transferrin
(metabolism)
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