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Comparison of changes in the uptake and mucosal processing of iron in riboflavin-deficient rats.

Abstract
Riboflavin deficiency in rats resulted in a reduction in the transfer of 59Fe from an intragastric dose to plasma compared to age-matched or weight-matched controls. The uptake of iron by brush-border membrane vesicles made from intestinal mucosa of riboflavin-deficient rats was much less than identically-prepared vesicles from control groups. Although the mucosal content of 59Fe was smaller in riboflavin-deficient rats thirty minutes after dosing, the relative distribution of 59Fe between the mucosal iron-binding proteins, ferritin and transferrin, was not changed compared to the control groups. These studies suggest that the impairment in iron absorption in riboflavin deficiency is primarily the result of a reduced uptake of iron into the mucosal cell and not a redistribution of iron between iron-binding proteins inside the mucosal cell.
AuthorsB F Butler, R W Topham
JournalBiochemistry and molecular biology international (Biochem Mol Biol Int) Vol. 30 Issue 1 Pg. 53-61 (May 1993) ISSN: 1039-9712 [Print] England
PMID8358336 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Hemoglobins
  • Transferrin
  • Ferritins
  • Iron
Topics
  • Animals
  • Body Weight
  • Ferritins (metabolism)
  • Hemoglobins (analysis)
  • Intestinal Mucosa (metabolism)
  • Iron (blood, metabolism)
  • Male
  • Microvilli (metabolism)
  • Organ Size
  • Rats
  • Riboflavin Deficiency (metabolism)
  • Transferrin (metabolism)

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