Decrease in vivo of cysteine endopeptidases in blood of patients with tumor of the larynx.

Abstract

Since cysteine endopeptidase (cathepsins B and L) have been proposed to be implicated in tumor malignancy, we have attempted to decrease these in vivo. Large amounts of urine cysteine peptidase inhibitors (UCPI) are present in the urine of patients. Our results indicate protective effects of a UCIP preparation against human serum cysteine endopeptidases.

• Authors: W Mikulewicz, I Berdowska, J Jarmułowicz, M Siewiński
• Journal: Anti-cancer drugs (Anticancer Drugs) Vol. 4 Issue 3 Pg. 341-4 (Jun 1993) ISSN: 0959-4973 [Print] England
• PMID: 8358062 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cysteine Proteinase Inhibitors
• Cysteine Endopeptidases

Topics

• Adult
• Chromatography, Affinity
• Cysteine Endopeptidases (blood, urine)
• Cysteine Proteinase Inhibitors (adverse effects, therapeutic use, urine)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Humans
• Laryngeal Neoplasms (drug therapy, enzymology, urine)
• Male