[99mTc-MAG3-kidney function scintigraphy without and with captopril in the diagnosis of renovascular hypertension].

Abstract

In this study, the diagnostic value of renal function scintigraphy performed both without and with ACE inhibition has been evaluated using the new radiopharmaceutical 99mTc-MAG3. In cases of decompensated renal artery stenoses, the typical scan finding with this tubular excreted agent was shown to be a distinct parenchymal nuclide retention in combination with a delayed appearance of the radiotracer in the pelvic system. Using this criterion in 43 patients with suspected renovascular hypertension, sensitivity and specificity were 89 and 88%, respectively. Bilateral positive findings were non-specific; excluding them from the study, specificity increased to 100%. In renal insufficiency, captopril scans seem to be of reduced diagnostic value. Summarising our experiences, renal function scintigraphy using 99mTc-MAG3 without and with captopril was proved to be a reliable non-invasive method to detect or exclude haemodynamically relevant renal artery stenosis.

• Authors: R Piepenburg, A Bockisch, J Andreas, C Düber, P Kann, G Maier, K Hahn
• Journal: RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin (Rofo) Vol. 159 Issue 2 Pg. 150-7 (Aug 1993) ISSN: 1438-9029 [Print] Germany
• Vernacular Title: 99mTc-MAG3-Nierenfunktionsszintigraphie ohne und mit Captopril zur Diagnostik der renovaskulären Hypertonie.
• PMID: 8353261 (Publication Type: Journal Article)

Chemical References

• Technetium Tc 99m Mertiatide
• Captopril

Topics

• Captopril (administration & dosage)
• Humans
• Hypertension, Renovascular (diagnostic imaging)
• Radionuclide Imaging
• Renal Artery Obstruction (diagnostic imaging)
• Sensitivity and Specificity
• Technetium Tc 99m Mertiatide