Carcinoma in situ of the glottis: radiotherapy or excision biopsy?

Abstract

Excision biopsy, radiotherapy, and laryngofissure cordectomy have all been used, but the best treatment regimen for glottic carcinoma in situ remains controversial. A 20-year experience of 37 cases is reported. For the first 10 years biopsy with radiotherapy was the first-line treatment (n = 20), but for the last 10 years surgical or laser excision biopsy alone has been performed (n = 17). The T stage of the carcinoma in situ does not determine its premalignant potential. Malignancy appears to be a recurrence, rather than a new expression of carcinogenesis. Excision biopsy alone provides local control results (75%) comparable to those of primary radiotherapy (85%). Excision biopsy alone, however, retains the option of subsequent radiotherapy with preservation of laryngeal function, but very close follow-up, especially in the first year, is required.

• Authors: G E Murty, J P Diver, P J Bradley
• Journal: The Annals of otology, rhinology, and laryngology (Ann Otol Rhinol Laryngol) Vol. 102 Issue 8 Pt 1 Pg. 592-5 (Aug 1993) ISSN: 0003-4894 [Print] United States
• PMID: 8352481 (Publication Type: Comparative Study, Journal Article)

Topics

• Biopsy (methods)
• Carcinoma in Situ (mortality, radiotherapy, surgery)
• Combined Modality Therapy
• Female
• Follow-Up Studies
• Glottis
• Humans
• Laryngeal Neoplasms (mortality, radiotherapy, surgery)
• Male
• Middle Aged
• Radiotherapy, High-Energy
• Smoking (epidemiology)
• Time Factors