Abstract |
The effect of methylflavonolamine [4'-methyl-7-(2-hydroxy-3-isopropylamino-propoxy)- flavone hydrochloride, MFA], synthesized recently by the Shanghai Institute of Pharmaceutical Industry, on the development of atherosclerosis was studied in male New Zealand white rabbits fed cholesterol for 10 wk. MFA, 7 mg.kg-1 daily ip, did not significantly alter the serum total cholesterol, HDL, and triglyceride levels, but significantly lowered the aortic cholesterol and calcium contents. Atheromatous lesions covered 53.3 +/- 11.8% of the intimal surface of the aorta in the saline group and 11.3 +/- 2.3% in the MFA group (P < 0.01). We conclude that MFA suppresses cholesterol-induced atherosclerosis.
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Authors | M S Zhang, E F Zhou, M Z Wang, X M Li |
Journal | Zhongguo yao li xue bao = Acta pharmacologica Sinica
(Zhongguo Yao Li Xue Bao)
Vol. 14
Issue 2
Pg. 133-6
(Mar 1993)
ISSN: 0253-9756 [Print] China |
PMID | 8352005
(Publication Type: Journal Article)
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Chemical References |
- Calcium Channel Blockers
- Cholesterol, Dietary
- Flavonoids
- Flavonols
- SIPI 549
- Cholesterol
- Calcium
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Topics |
- Animals
- Aorta
(metabolism)
- Arteriosclerosis
(etiology, prevention & control)
- Calcium
(blood)
- Calcium Channel Blockers
(pharmacology, therapeutic use)
- Cholesterol
(blood)
- Cholesterol, Dietary
(administration & dosage)
- Flavonoids
(pharmacology, therapeutic use)
- Flavonols
- Male
- Rabbits
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