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Methylflavonolamine protects aorta from atherosclerosis in cholesterol-fed rabbits.

Abstract
The effect of methylflavonolamine [4'-methyl-7-(2-hydroxy-3-isopropylamino-propoxy)-flavone hydrochloride, MFA], synthesized recently by the Shanghai Institute of Pharmaceutical Industry, on the development of atherosclerosis was studied in male New Zealand white rabbits fed cholesterol for 10 wk. MFA, 7 mg.kg-1 daily ip, did not significantly alter the serum total cholesterol, HDL, and triglyceride levels, but significantly lowered the aortic cholesterol and calcium contents. Atheromatous lesions covered 53.3 +/- 11.8% of the intimal surface of the aorta in the saline group and 11.3 +/- 2.3% in the MFA group (P < 0.01). We conclude that MFA suppresses cholesterol-induced atherosclerosis.
AuthorsM S Zhang, E F Zhou, M Z Wang, X M Li
JournalZhongguo yao li xue bao = Acta pharmacologica Sinica (Zhongguo Yao Li Xue Bao) Vol. 14 Issue 2 Pg. 133-6 (Mar 1993) ISSN: 0253-9756 [Print] China
PMID8352005 (Publication Type: Journal Article)
Chemical References
  • Calcium Channel Blockers
  • Cholesterol, Dietary
  • Flavonoids
  • Flavonols
  • SIPI 549
  • Cholesterol
  • Calcium
Topics
  • Animals
  • Aorta (metabolism)
  • Arteriosclerosis (etiology, prevention & control)
  • Calcium (blood)
  • Calcium Channel Blockers (pharmacology, therapeutic use)
  • Cholesterol (blood)
  • Cholesterol, Dietary (administration & dosage)
  • Flavonoids (pharmacology, therapeutic use)
  • Flavonols
  • Male
  • Rabbits

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