[Thrombolytic effect of plasmin, miniplasmin and fibrinolysin in simulated intraocular hemorrhage].

Abstract

The fibrinolytic properties of the preparations of plasmin (Pm), mixture of plasminogen and streptokinase (Pg+Sk), miniplasmin (m-Pm) and fibrinolysin have been investigated on the models of rabbit's hyphema. The action of preparations of Pm and Pg+Sk had approximately equal therapeutic index--the total destruction of clots proceeded for 12.0 days, that was 6.6 days less than in the control group. The therapeutic effect for m-Pm was 3.6 days. The dose of preparation of m-Pm, necessary for total destruction of clots, was 15-20% greater than for the same dose of Pg+Sk. The preparation of fibrinolysin, used in the same quantities of proteolytic activity, as Pg and m-Pg, (16 caseinolytic units per 1 injection) had no therapeutic effect.

• Authors: I P Metelitsyna, O S Petretskaia, S S Rodin, S I Andrianov
• Journal: Ukrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1993 Jan-Feb Vol. 65 Issue 1 Pg. 93-7 ISSN: 0201-8470 [Print] Ukraine
• Vernacular Title: Tromboliticheskoe deĭstvie plazmina, miniplazmina i fibrinolizina v usloviiakh modelirovaniia vnutriglaznogo krovoizliianiia.
• PMID: 8351749 (Publication Type: English Abstract, Journal Article)

Chemical References

• Peptide Fragments
• miniplasmin
• Fibrinolysin

Topics

• Animals
• Disease Models, Animal
• Fibrinolysin (therapeutic use)
• Hyphema (drug therapy)
• Peptide Fragments (therapeutic use)
• Rabbits