Bioactive and other sesquiterpenoids from Porella cordeana.

Abstract

Bioassay-directed fractionation of the MeCOEt extract of Porella cordeana yielded drimenin [1] and aristolone [4], which were moderately toxic towards DNA-repair-deficient mutants of Saccharomyces cerevisiae. Three inactive sesquiterpenes, 7-ketoisodrimenin [2], 7-ketoisodrimenin-5-ene [3], and norpinguisanolide, were also obtained. Compounds 2 and 3 are new.

• Authors: G G Harrigan, A Ahmad, N Baj, T E Glass, A A Gunatilaka, D G Kingston
• Journal: Journal of natural products (J Nat Prod) Vol. 56 Issue 6 Pg. 921-5 (Jun 1993) ISSN: 0163-3864 [Print] United States
• PMID: 8350093 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Sesquiterpenes

Topics

• Animals
• CHO Cells
• Cricetinae
• DNA Repair (drug effects)
• Leukemia P388 (pathology)
• Magnetic Resonance Spectroscopy
• Mass Spectrometry
• Mice
• Plants, Medicinal (chemistry)
• Saccharomyces cerevisiae (drug effects, metabolism)
• Sesquiterpenes (chemistry, isolation & purification, pharmacology)
• Spectrophotometry, Infrared
• Spectrophotometry, Ultraviolet