Identification of galegine, an isoprenyl guanidine, as the toxic principle of Schoenus asperocarpus (poison sedge).

Abstract

An isoprenyl guanidine, galegine, was isolated from the Western Australian sedge Schoenus asperocarpus (Cyperaceae). Synthetic galegine was shown to reproduce the clinical and pathological features of poisoning by this plant. Preliminary results suggest that the massive thoracic effusion observed in sedge poisoning is the result of a direct effect on pulmonary vascular permeability.

• Authors: C R Huxtable, P R Dorling, S M Colegate
• Journal: Australian veterinary journal (Aust Vet J) Vol. 70 Issue 5 Pg. 169-71 (May 1993) ISSN: 0005-0423 [Print] England
• PMID: 8343085 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Guanidines
• galegine

Topics

• Animals
• Female
• Guanidines (isolation & purification, toxicity)
• Injections, Intraperitoneal
• Lung Diseases (chemically induced, pathology, veterinary)
• Male
• Plants, Toxic (chemistry)
• Sheep
• Sheep Diseases (chemically induced, pathology)