Abstract |
To assess the effect of ticlopidine on the cutaneous circulation, 25 patients with lower limb ischemia were investigated just before and at two hours after being given a 200 mg oral dose of ticlopidine. The transcutaneous partial pressure of oxygen (PtcO2) and the skin temperature were determined at 35 limb sites and 9 chest walls sites. Both the PtcO2 and the skin temperature were significantly increased at two hours after the administration of ticlopidine (p < 0.01). The findings suggest that ticlopidine can improve the cutaneous microcirculation in patients with peripheral vascular disease.
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Authors | S Qian, T Iwai |
Journal | Angiology
(Angiology)
Vol. 44
Issue 8
Pg. 627-31
(Aug 1993)
ISSN: 0003-3197 [Print] United States |
PMID | 8342879
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Aged
- Blood Gas Monitoring, Transcutaneous
- Drug Evaluation
- Female
- Gangrene
(blood, drug therapy, physiopathology)
- Humans
- Intermittent Claudication
(blood, drug therapy, physiopathology)
- Ischemia
(blood, drug therapy, physiopathology)
- Leg
(blood supply)
- Male
- Middle Aged
- Peripheral Vascular Diseases
(blood, drug therapy, physiopathology)
- Skin
(blood supply, drug effects)
- Skin Temperature
(drug effects)
- Thorax
- Ticlopidine
(therapeutic use)
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