Introductory trial of the once-a-month injectable contraceptive, Cyclofem, in Indonesia.

Abstract

Cyclofem, a once-a-month injectable hormone contraceptive, contains medroxyprogesterone acetate, 25 mg and estradiol cypionate, 5 mg. Indonesia is one of the countries participating in an introductory trial in collaboration with the World Health Organization (WHO) under the Human Reproduction Program (HRP). The main purpose of the trial is to assess, through a limited cohort of users, both problems and user needs in the program situation with regard to safety, efficacy, acceptability, and causes of discontinuation in the Indonesian context. Data based on the trial (March 1990-February 1992) indicate that the Cyclofem women complained of dizziness, nausea, bleeding problems, migraine, vomiting, amenorrhea, allergies and hypertension during the use of Cyclofem. However, it was found that the complaint rates decreased with increased duration of use. The life table continuation rates indicate that about 80% and 66% continued use at the end of 6 months and 12 months, respectively. Personal reasons account for the highest proportion of discontinuation, followed by desire for pregnancy and lost-to-follow-up.

• Authors: S P Pandi, L N Hadjar, T Prihyugiharto
• Journal: Advances in contraception : the official journal of the Society for the Advancement of Contraception (Adv Contracept) Vol. 9 Issue 1 Pg. 33-40 (Mar 1993) ISSN: 0267-4874 [Print] Netherlands
• PMID: 8342452 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Contraceptive Agents, Female
• Contraceptives, Oral, Combined
• Drug Combinations
• Estradiol
• CycloProvera
• estradiol 17 beta-cypionate
• Medroxyprogesterone Acetate

Topics

• Adult
• Contraceptive Agents, Female (administration & dosage, adverse effects, standards)
• Contraceptives, Oral, Combined (administration & dosage, adverse effects, standards)
• Dose-Response Relationship, Drug
• Drug Combinations
• Estradiol (administration & dosage, adverse effects, analogs & derivatives, standards)
• Family Planning Services
• Female
• Humans
• Indonesia
• Injections
• Life Tables
• Medroxyprogesterone Acetate (administration & dosage, adverse effects, standards)
• Time Factors
• World Health Organization