The association of HLA-B8, B51, DR2, and multiple sclerosis in pars planitis.

Abstract

PURPOSE:

To establish a human leukocyte antigen (HLA) association in a homogeneous population of patients with pars planitis.

METHODS:

A strict set of inclusion parameters was established for the diagnosis of pars planitis. Forty patients with pars planitis who met these criteria underwent HLA analysis of class I and II phenotypes.

RESULTS:

HLA-B8 was present in 15 (37.5%) of 40 patients versus 85 (19.7%) of 431 controls (relative risk, 2.44; P = 0.011). HLA-B51 was present in 9 (22.5%) of 40 patients versus 51 (11.8%) of 431 controls (relative risk, 2.16; P = 0.049). HLA-DR2 was present in 27 (67.5%) of 40 patients versus 121 (28.0%) of 431 controls (relative risk, 5.32; P < 0.0001). HLA-DR2 has been associated with multiple sclerosis (MS). Exclusion of five patients with pars planitis in whom MS subsequently developed did not change the significance of these findings.

CONCLUSIONS:

The strongest association of pars planitis with HLA-DR2 and the temporal development of MS in some patients with pars planitis further supports an association between pars planitis and MS.

• Authors: S M Malinowski, J S Pulido, N E Goeken, C K Brown, J C Folk
• Journal: Ophthalmology (Ophthalmology) Vol. 100 Issue 8 Pg. 1199-205 (Aug 1993) ISSN: 0161-6420 [Print] United States
• PMID: 8341502 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-A Antigens
• HLA-B Antigens
• HLA-B8 Antigen
• HLA-D Antigens
• HLA-DR2 Antigen

Topics

• Case-Control Studies
• Female
• HLA-A Antigens (genetics)
• HLA-B Antigens (genetics)
• HLA-B8 Antigen
• HLA-D Antigens (genetics)
• HLA-DR2 Antigen
• Humans
• Male
• Multiple Sclerosis (etiology, immunology)
• Pars Planitis (complications, immunology)
• Phenotype