The adenosine kinase inhibitor, 5-iodotubercidin, is not protective against cerebral ischemic injury in the gerbil.

Abstract

5-Iodotubercidin is a potent inhibitor of the enzyme adenosine kinase. It has a recognized ability to enhance interstitial fluid levels of the cerebroprotective purine, adenosine, in the hypoxic brain, and an anticonvulsant action, which is thought to be a consequence of its ability to increase extracellular adenosine levels. 5-Iodotubercidin (1 mg/kg, i.p.) was therefore tested for its ability to reduce cerebral ischemic injury in a gerbil model. Unanesthetized gerbils were subjected to a 5 min period of bilateral carotid artery occlusion and then maintained in an environmental chamber at 30 degrees C for 5 hr to counteract the hypothermia-inducing action of 5-iodotubercidin. As estimated from the extent of the increases in locomotor activity and the magnitude of hippocampal CAI layer pyramidal cell loss, 5-iodotubercidin (1 mg/kg) failed to have a cerebroprotective effect against ischemic injury.

• Authors: J W Phillis, M Smith-Barbour
• Journal: Life sciences (Life Sci) Vol. 53 Issue 6 Pg. 497-502 ( 1993) ISSN: 0024-3205 [Print] Netherlands
• PMID: 8341136 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• 5-iodotubercidin
• Adenosine Kinase
• Tubercidin

Topics

• Adenosine Kinase (antagonists & inhibitors)
• Animals
• Body Temperature (drug effects)
• Brain Ischemia (pathology, physiopathology, prevention & control)
• Gerbillinae
• Hippocampus (drug effects, pathology)
• Male
• Motor Activity (drug effects)
• Tubercidin (analogs & derivatives, pharmacology)