Abstract | OBJECTIVE: DESIGN: Prospective, randomized, controlled study. SETTING: An animal laboratory of a university hospital. Four sequential global and regional cerebral blood flow determinations were made in each animal during monitoring of heart rate and systemic arterial pressure, during respiratory control and arterial blood gas monitoring, intracranial pressure monitoring, and with or without inflation of an epidural balloon catheter. SUBJECTS: INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: The main outcome measures were changes in intracranial pressure and/or changes in regional or total cerebral blood flow. A significant decrease in intracranial pressure and cerebral blood flow rate was produced by hyperventilation alone in groups with intracranial hypertension. Combined hyperventilation and barbiturate therapy resulted in a significant further decrease in cerebral blood flow rate in animals with normal and increased intracranial pressure, but no greater decrease in intracranial pressure was seen compared with treatment with hyperventilation alone. Cerebral perfusion pressures remained normal despite significant decreases in cerebral blood flow rates. CONCLUSIONS:
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Authors | P T Louis, J Goddard-Finegold, M A Fishman, J R Griggs, F Stein, J P Laurent |
Journal | Critical care medicine
(Crit Care Med)
Vol. 21
Issue 8
Pg. 1200-6
(Aug 1993)
ISSN: 0090-3493 [Print] United States |
PMID | 8339587
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Acute Disease
- Animals
- Blood Flow Velocity
(drug effects)
- Blood Gas Analysis
- Cerebrovascular Circulation
(drug effects)
- Combined Modality Therapy
- Dogs
- Drug Evaluation, Preclinical
- Evaluation Studies as Topic
- Female
- Hemodynamics
(drug effects)
- Intracranial Pressure
- Male
- Pentobarbital
(administration & dosage, pharmacology, therapeutic use)
- Pseudotumor Cerebri
(blood, physiopathology, therapy)
- Random Allocation
- Respiration, Artificial
(methods)
- Vascular Resistance
(drug effects)
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