Abstract | BACKGROUND: Dedifferentiated chordoma is an unusual and aggressive variant of chordoma which is likely to metastasize. Few reports exist of treatment of these tumors with chemotherapy. METHODS: In 1988, two patients with dedifferentiated sacral chordomas were seen at the University of Chicago Hospitals. Both developed metastatic disease less than a year after sacral resection and radiation therapy. These patients' diagnoses, courses, and treatments were reviewed along with the literature on chemotherapy in both conventional and dedifferentiated chordomas. RESULTS: Both patients obtained complete remissions, one to a six- drug regimen and the other to ifosfamide. CONCLUSIONS: A trial of reasonably aggressive chemotherapy is warranted in patients with metastatic dedifferentiated chordoma. The optimum regimen is unclear, but agents active in high-grade sarcomas are logical choices.
|
Authors | G F Fleming, P S Heimann, J K Stephens, M A Simon, M K Ferguson, R S Benjamin, B L Samuels |
Journal | Cancer
(Cancer)
Vol. 72
Issue 3
Pg. 714-8
(Aug 01 1993)
ISSN: 0008-543X [Print] United States |
PMID | 8334623
(Publication Type: Case Reports, Journal Article, Review)
|
Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bone Neoplasms
(pathology)
- Chordoma
(drug therapy, pathology, secondary)
- Female
- Humans
- Lung Neoplasms
(drug therapy, pathology, secondary)
- Neoplasm Recurrence, Local
(surgery)
- Sacrum
|