Cyclosporine-induced hemolytic uremic syndrome in a heart transplant recipient.

Abstract

We report a case of hemolytic uremic syndrome associated with the use of cyclosporine in a heart transplant recipient. The patient manifested many classic signs and symptoms of hemolytic uremic syndrome, and a diagnosis was confirmed by kidney biopsy. Treatment with plasma exchange was effective in halting the hemolysis, but renal function failed to improve. Rechallenge with cyclosporine caused recurrence of microangiopathic hemolysis. Because of concerns regarding allograft rejection, an experimental immunosuppressive agent, RS-61443, was used that was effective in controlling rejection and was not associated with recurrence of hemolytic uremic syndrome.

• Authors: F C Galli, L E Damon, S J Tomlanovich, F Keith, K Chatterjee, T DeMarco
• Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (J Heart Lung Transplant) 1993 May-Jun Vol. 12 Issue 3 Pg. 440-4 ISSN: 1053-2498 [Print] United States
• PMID: 8329415 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cyclosporine

Topics

• Cyclosporine (adverse effects, therapeutic use)
• Heart Transplantation
• Hemolytic-Uremic Syndrome (chemically induced, pathology)
• Humans
• Kidney (pathology)
• Male
• Middle Aged