HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Anti-ENA antibody determination in various connective tissue diseases: comparison of 2 detection techniques].

Abstract
The authors compared two different techniques for the detection of anti-ENA antibodies (anti-Sm, anti-RNP, anti-SSA, anti-SSB) in several different connective tissue diseases, using double immunodiffusion (ID) and a new membrane-based enzyme immunoassay. The aim of the work was to research the assay sensibility and specificity of the results obtained with the two different methods. Notwithstanding the fact that the two techniques are equivalent in their performance, the recombinant DNA appears to have greater sensibility and less specificity compared to ID. The former requires less time of execution although it presents difficulty in interpreting low scale positive results. Although the number of sera examined was low, the authors assert that the recombinant DNA technique will require further development.
AuthorsD Vaccai, V Cataldi, G Morozzi, M R Bacarelli, A Ciali, G Pucci, R Marcolongo
JournalBollettino della Societa italiana di biologia sperimentale (Boll Soc Ital Biol Sper) Vol. 69 Issue 1 Pg. 45-8 (Jan 1993) ISSN: 0037-8771 [Print] Italy
Vernacular TitleDeterminazione di anticorpi anti-ENA in alcune connettiviti: confronto di due tecniche di rilevazione.
PMID8329190 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Antibodies, Antinuclear
  • DNA, Recombinant
Topics
  • Adolescent
  • Adult
  • Antibodies, Antinuclear (blood)
  • Connective Tissue Diseases (immunology)
  • DNA, Recombinant
  • Female
  • Humans
  • Immunodiffusion
  • Immunoenzyme Techniques
  • Male
  • Middle Aged
  • Sensitivity and Specificity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: