Therapeutic activity of SK&F 105685, a novel azaspirane with suppressor-cell inducing activity.

Abstract	SK&F 105685, methotrexate (MTX) and chloroquine (CHL) were examined for their ability to inhibit paw inflammation in the adjuvant arthritic rat (AA) and for their ability to induce non-specific suppressor cells (SC) in the spleens of these animals. Compared to SK&F 105685 (84-90%) inhibition and MTX (91% inhibition) CHL, at the maximally tolerated dose, only inhibited paw lesions by 29%. MTX did not induce splenic SC activity and, despite the structural similarities between CHL and SK&F 105685, only the latter induced suppressor cells.
Authors	A M Badger, B A Swift
Journal	Clinical and experimental rheumatology (Clin Exp Rheumatol) 1993 Mar-Apr Vol. 11 Suppl 8 Pg. S107-9 ISSN: 0392-856X [Print] Italy
PMID	8324933 (Publication Type: Comparative Study, Journal Article)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Spiro Compounds SK&F 105685 Chloroquine Methotrexate
Topics	Animals Anti-Inflammatory Agents, Non-Steroidal (therapeutic use) Arthritis, Experimental (drug therapy, immunology) Chloroquine (therapeutic use) Methotrexate (therapeutic use) Rats Rats, Inbred Lew Spiro Compounds (therapeutic use) T-Lymphocytes, Regulatory (drug effects, immunology)

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