HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[The inhibiting effect of ortofen and indomethacin in relation to the development of induced nervous system tumors in rats].

Abstract
The anticarcinogenic effects of the nonsteroidal antiinflammatory drugs ortophen and indomethacin on carcinogenesis of the nervous and renal systems were studied. Glial tumors of the brain and spinal cord, neurinomas of peripheral nerves and renal mesenchymal tumors were induced in rats through a single transplacental administration of N-ethyl-N-nitrosourea, 75 mg/kg body weight. Ortophen and indomethacin each used in a dose of 20 mg/litre of drinking water in the period of postnatal life were effective in inhibiting the growth of brain and spinal cord tumors, showed a statistically insignificant tendency to suppress the growth of peripheral nervous tumors, but failed to affect the growth of renal tumors.
AuthorsV G Bespalov, V A Aleksandrov, A S Petrov, M Iu Lidak
JournalEksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1993 Jan-Feb Vol. 56 Issue 1 Pg. 52-4 ISSN: 0869-2092 [Print] Russia (Federation)
Vernacular TitleTormoziashchiĭ éffekt ortofena i indometatsina v otnoshenii razvitiia indutsirovannykh opukholeĭ nervnoĭ sistemy u krys.
PMID8324478 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Diclofenac
  • Ethylnitrosourea
  • Indomethacin
Topics
  • Animals
  • Antineoplastic Agents (therapeutic use)
  • Diclofenac (therapeutic use)
  • Drug Screening Assays, Antitumor
  • Ethylnitrosourea
  • Female
  • Indomethacin (therapeutic use)
  • Kidney Neoplasms (chemically induced, prevention & control)
  • Nervous System Neoplasms (chemically induced, prevention & control)
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Rats
  • Rats, Wistar

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: