Abstract | BACKGROUND AND PURPOSE: The frequency and prognostic significance of neuroradiological findings after cardiac arrest are unknown. Using healthy volunteers as control subjects, we studied the magnetic resonance imaging (MRI) findings associated with cardiac arrest, adjusted for confounding factors. METHODS: RESULTS:
Cardiac arrest was an independent risk factor for the presence of infarcts in a logistic regression model adjusted for age, sex, and history of myocardial infarction, stroke, coronary heart disease, cardiac failure, and hypertension (odds ratio, 3.6; 95% confidence interval, 1.3 to 9.9; P = .01). Leukoaraiosis was associated with increasing age but not with cardiac arrest. Adjusted for age, the delay of advanced life support had an inverse correlation with the degree of atrophy in placebo-treated patients (r = -.62, P < .0001) but not in patients treated with nimodipine (r = -.10, P = .43). Lack of age-related atrophy, possibly implicating the presence of brain edema, predicted poor outcome after cardiac arrest (odds ratio, 4.6; 95% confidence interval, 1.4 to 15.8; P = .01). CONCLUSIONS:
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Authors | R O Roine, R Raininko, T Erkinjuntti, A Ylikoski, M Kaste |
Journal | Stroke
(Stroke)
Vol. 24
Issue 7
Pg. 1005-14
(Jul 1993)
ISSN: 0039-2499 [Print] United States |
PMID | 8322374
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Age Factors
- Aged
- Atrophy
(diagnosis, etiology)
- Brain Edema
(diagnosis, drug therapy, etiology)
- Cerebral Infarction
(diagnosis, etiology)
- Double-Blind Method
- Female
- Heart Arrest
(complications, diagnosis, drug therapy)
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Nimodipine
(therapeutic use)
- Prognosis
- Risk Factors
- Treatment Outcome
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