Abstract |
Melanocytic tumors as well as multiple neurofibromas were induced in 35 of 88 Syrian golden hamsters by a single s.c. administration of 100 mg/kg of N-nitroso- N-ethylurea applied 48 h after birth. The lesions were all observed proliferating in the dermis and demonstrated melanosomes and premelanosomes. High cellularity, nuclear atypia and transplantability of the tumors in outbred hamsters suggested a malignant nature. Some of the melanomas were morphologically heterogenous and contained Schwann-like cells as minor components. In addition, transplantation of the melanomas resulted in increased schwannian differentiation even for primary tumors which did not contain any Schwann-like cell foci. One of the transplanted melanomas mimicked malignant peripheral nervous tumor. Schwannian differentiation was also proved by the fact that glial fibrillary acidic protein was positive in 22.2% of the cases. The present results suggest that the induced hamster melanomas originate from neural crest-derived cells which are able to differentiate into both melanocytes and Schwann cells.
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Authors | T Nemoto, T Nakamura, K Ohashi, T Kasuga |
Journal | Japanese journal of cancer research : Gann
(Jpn J Cancer Res)
Vol. 84
Issue 5
Pg. 512-7
(May 1993)
ISSN: 0910-5050 [Print] Japan |
PMID | 8320168
(Publication Type: Journal Article)
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Chemical References |
- Glial Fibrillary Acidic Protein
- Ethylnitrosourea
|
Topics |
- Animals
- Cell Differentiation
- Cricetinae
- Ethylnitrosourea
(toxicity)
- Female
- Glial Fibrillary Acidic Protein
(analysis)
- Immunohistochemistry
- Male
- Melanoma, Experimental
(chemically induced, pathology, ultrastructure)
- Mesocricetus
- Microscopy, Electron
- Neoplasm Transplantation
- Schwann Cells
(pathology)
- Sex Factors
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