The uptake of manganese dipyridoxal-diphosphate by chemically induced hepatocellular carcinoma in rats. A correlation between contrast-media-enhanced magnetic resonance imaging, tumor differentiation, and vascularization.

Abstract

OBJECTIVES AND RATIONALE:

Negative enhancement of implanted liver tumors has been achieved in preclinical studies on manganese dipyridoxal-diphosphate (Mn-DPDP), a new hepatobiliary specific contrast agent for magnetic resonance imaging (MRI). The authors investigated the effects of Mn-DPDP on primary liver cancer and its possible mechanisms.

METHODS:

Magnetic resonance imaging was performed in 15 rats with chemically induced hepatocellular carcinoma (HCC) before and after Mn-DPDP injection. Both tumor-liver contrast-to-noise ratio and absolute tumor enhancement were evaluated and compared with the MRI results of a nonspecific contrast agent, gadolinium-DOTA, and correlated with corresponding microangiographic and histologic findings.

RESULTS:

Mn-DPDP injection led to a persistent positive enhancement in differentiated solid HCCs (22/23) with maximal conspicuity at 24 hours. Undifferentiated HCCs were all delineated by a prompt negative enhancement (20/20) with maximal conspicuity within 30 minutes.

• Authors: Y Ni, G Marchal, X Zhang, P Van Hecke, J Michiels, J Yu, E Rummeny, K P Lodemann, A L Baert
• Journal: Investigative radiology (Invest Radiol) Vol. 28 Issue 6 Pg. 520-8 (Jun 1993) ISSN: 0020-9996 [Print] United States
• PMID: 8320070 (Publication Type: Journal Article)

Chemical References

• Contrast Media
• Heterocyclic Compounds
• Organometallic Compounds
• Pyridoxal Phosphate
• gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate
• Edetic Acid
• N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid

Topics

• Angiography
• Animals
• Contrast Media
• Edetic Acid (analogs & derivatives)
• Heterocyclic Compounds
• Liver Neoplasms, Experimental (blood supply, diagnosis, pathology)
• Magnetic Resonance Imaging
• Male
• Microradiography
• Organometallic Compounds
• Pyridoxal Phosphate (analogs & derivatives)
• Rats
• Rats, Wistar