[Analysis of binding capacities between HLA class II molecules and synthetic peptides HA307-319].

Abstract

MHC class II molecules control immune responses for T cell recognition of peptide antigens. In this study, we have examined the lymphocyte proliferative response (LPR) for HA307-319, a synthetic peptide, derived from hemagglutinin of a human influenza virus A strain, and the binding capacities of several DR and DQ molecules, which are frequently expressed in Japanese, with HA307-319. The high response of lymphocytes to HA307-319 was observed in DR1-positive subjects, and DR1 molecules had higher binding capacitise than DR2 and DR9 with the peptide. Also, three types of DQ molecules could bind weakly with HA307-319.

• Authors: K Ikeda, M Katagiri
• Journal: [Hokkaido igaku zasshi] The Hokkaido journal of medical science (Hokkaido Igaku Zasshi) Vol. 68 Issue 3 Pg. 318-24 (May 1993) ISSN: 0367-6102 [Print] Japan
• PMID: 8319931 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hemagglutinin Glycoproteins, Influenza Virus
• Hemagglutinins, Viral
• Histocompatibility Antigens Class II
• Peptide Fragments
• Peptides
• influenza hemagglutinin (307-319)

Topics

• Amino Acid Sequence
• Cells, Cultured
• Hemagglutinin Glycoproteins, Influenza Virus
• Hemagglutinins, Viral
• Histocompatibility Antigens Class II (metabolism)
• Humans
• Lymphocyte Activation
• Lymphocytes (immunology)
• Molecular Sequence Data
• Peptide Fragments
• Peptides (metabolism)
• Protein Binding