Anticonvulsant activity of the gamma-aminobutyric acid uptake inhibitor N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol .

Abstract

The N-4,4-diphenyl-3-butenyl derivative of the glial selective gamma-aminobutyric acid (GABA) uptake inhibitor 4,5,6,7-tetrahydroisoxazolo [4,5-c]pyridin-3-ol (N-DPB-THPO), was tested for its ability to block sound-induced seizures in the audiogenic seizure-susceptible Frings mouse model of epilepsy. Following intracerebroventricular (i.c.v.) administration, N-DPB-THPO blocked tonic hindlimb extension in a dose- and time-dependent manner. At the doses tested no gross behavioral effects were noted.

• Authors: H S White, J Hunt, H H Wolf, E A Swinyard, E Falch, P Krogsgaard-Larsen, A Schousboe
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 236 Issue 1 Pg. 147-9 (May 12 1993) ISSN: 0014-2999 [Print] Netherlands
• PMID: 8319739 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anticonvulsants
• GABA Antagonists
• Isoxazoles
• N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol
• gamma-Aminobutyric Acid

Topics

• Acoustic Stimulation
• Animals
• Anticonvulsants (administration & dosage, pharmacology)
• Dose-Response Relationship, Drug
• GABA Antagonists
• Injections, Intraventricular
• Isoxazoles (pharmacology)
• Mice
• Seizures (prevention & control)
• gamma-Aminobutyric Acid (metabolism)