In-111 CYT-103 immunoscintigraphy in the imaging of ovarian carcinoma.

Abstract

Fifteen presurgical patients with a history of ovarian carcinoma were evaluated with immunoscintigraphy using the In-111-labeled monoclonal antibody conjugate CYT-103. Twelve of these patients had residual neoplasia at time of laparotomy. A single intravenous dose of the radiolabeled monoclonal antibody was given to these patients before restaging laparotomy. All patients also underwent CT scanning of the abdomen and pelvis before laparotomy. Immunoscintigraphy detected the presence of disease in 10 of 12 patients before surgery, whereas CT scanning detected disease in only 6 of these 12 women. The results of this study indicate that immunoscintigraphy using In-111 CYT-103 is more sensitive than CT and may add useful information to the preoperative evaluation of women with ovarian carcinoma.

• Authors: C E Neal, M R Baker, R D Hilgers, J Fanning, R C Burke, J Snodgrass, R D Cull
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 18 Issue 6 Pg. 472-6 (Jun 1993) ISSN: 0363-9762 [Print] United States
• PMID: 8319398 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Indium 111In-satumomab pendetide
• Indium Radioisotopes
• Oligopeptides
• Pentetic Acid

Topics

• Antibodies, Monoclonal
• Female
• Humans
• Indium Radioisotopes
• Laparotomy
• Middle Aged
• Neoplasm Recurrence, Local (diagnostic imaging, epidemiology)
• Oligopeptides
• Ovarian Neoplasms (diagnostic imaging, epidemiology)
• Pentetic Acid (analogs & derivatives)
• Prospective Studies
• Radioimmunodetection
• Sensitivity and Specificity
• Tomography, X-Ray Computed