Effects of (-)-pindolol and SDZ 216-525 on social and agonistic behavior in mice.

Abstract

In view of conflicting results reported for 5-HT1A receptor involvement in murine social conflict, this study examined the effect of two compounds, SDZ 216-525 and (-)-pindolol, on agonistic and social behavior in male mice. In a resident-intruder paradigm, (-)-pindolol (1.0-20.0 mg/kg), a beta-adrenergic 5-HT1A/1B antagonist, significantly attenuated all agonistic behaviors across the dose range employed. Social behaviors showed significant decreases, while nonsocial cage exploration showed significant increases at all doses. Defensive evade was significantly attenuated at 20.0 mg/kg. SDZ 216-525 (0.025-1.0 mg/kg), a selective 5-HT1A antagonist, significantly attenuated offensive posturing and bite-attacks at 1.0 mg/kg, and all offensive behaviors nonsignificantly at the smaller doses tested. Rearing was significantly attenuated at 1.0 mg/kg, while cage exploration increased at this dose. Defensive and social behaviors remained largely unchanged. These results show that both compounds tested produced significant reductions in offensive behavior, with concomitant changes in defensive, social, and nonsocial behaviors. Results are discussed in relation to SDZ 216-525 and (-)-pindolol potential for the control of anxiety and agonistic behavior.

• Authors: R Bell, H Hobson
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 46 Issue 4 Pg. 873-80 (Dec 1993) ISSN: 0091-3057 [Print] United States
• PMID: 8309968 (Publication Type: Journal Article)

Chemical References

• Indoles
• Serotonin Antagonists
• Thiazoles
• SDZ 216-525
• Pindolol

Topics

• Agonistic Behavior (drug effects)
• Animals
• Conflict, Psychological
• Exploratory Behavior (drug effects)
• Indoles (pharmacology)
• Male
• Mice
• Pindolol (pharmacology)
• Serotonin Antagonists (pharmacology)
• Social Behavior
• Thiazoles (pharmacology)