[Clinical evaluation of S-1108 in pediatric field].

Abstract

Nine pediatric patients with bacterial infections (5 cases of tonsillitis, 3 cases of impetigo and 1 case of UTI) were treated with S-1108, and the efficacy and the safety were evaluated. The clinical responses to S-1108 treatment were excellent in 7 cases and good in 2. The efficacy rate was 100%. Bacteriologically, the causative organisms (Streptococcus pyogenes, Staphylococcus aureus, Haemophilus parainfluenzae and Escherichia coli) were eradicated. No clinical side effects were observed. Elevation of CK in 2 cases and eosinophilia in 1 case were noted.

• Authors: T Nishimura, K Sugita, S Aoki, M Takagi
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 46 Issue 11 Pg. 1035-9 (Nov 1993) ISSN: 0368-2781 [Print] Japan
• PMID: 8309067 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cephalosporins
• S 1108
• S 1006
• Creatine Kinase

Topics

• Bacteria (drug effects, isolation & purification)
• Bacterial Infections (drug therapy, microbiology)
• Cephalosporins (adverse effects, pharmacology, therapeutic use)
• Child
• Child, Preschool
• Creatine Kinase (blood)
• Drug Evaluation
• Eosinophilia (chemically induced)
• Female
• Humans
• Infant
• Male
• Microbial Sensitivity Tests