[Clinical evaluation of S-1108 in children].

Abstract

We administered S-1108 to 16 children with ages ranging from 7 month to 15 years at doses between 1.8 and 6.0 mg/kg x 3/day for 3 to 13 days. We evaluated the efficacy and safety of S-1108 in 11 children with respiratory tract infections, 3 urinary tract infections, and 2 skin infections. The efficacy rate of S-1108 was 100% and bacteriological eradication rate was 83.3%. No adverse effects were observed. These results suggested that S-1108 could be used safely in children.

• Authors: K Kitamura, T Ihara, H Kamiya, E Azuma, M Ito, M Sakurai
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 46 Issue 11 Pg. 1025-9 (Nov 1993) ISSN: 0368-2781 [Print] Japan
• PMID: 8309065 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cephalosporins
• S 1108

Topics

• Adolescent
• Bacteria (drug effects, isolation & purification)
• Bacterial Infections (drug therapy, metabolism, microbiology)
• Cephalosporins (pharmacokinetics, pharmacology, therapeutic use)
• Child
• Child, Preschool
• Drug Evaluation
• Female
• Humans
• Infant
• Male
• Microbial Sensitivity Tests
• Respiratory Tract Infections (drug therapy)
• Skin Diseases, Bacterial (drug therapy)
• Urinary Tract Infections (drug therapy)