[Clinical studies on S-1108 in the field pediatrics].

Abstract

Clinical studies on S-1108, a new oral cephem antibiotic, were carried out in the field of pediatrics. The following results were obtained. 1. The peak plasma level of S-1006 when administered after meal at a dose of 4 mg/kg was 2.47 micrograms/ml at an hour, and the serum half-life was 0.81 hour. The 4 hours urinary excretion rate of S-1006 was 35.7%. 2. S-1108 was administered to 15 children with various infections (3 patients with pneumonia, 3 with acute bronchitis, 4 with scarlet fever, 2 with acute tonsillitis, 1 with phlegmon and 2 with urinary tract infections). The overall clinical efficacy rate was 100%. 3. Side effects or abnormal laboratory test values were not observed except for diarrhea in 1 and eosinophilia in 1.

• Authors: K Kuno, A Ogawa, F Hayakawa, K Ito, M Kondo, A Okumura, J Natsume
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 46 Issue 11 Pg. 1017-24 (Nov 1993) ISSN: 0368-2781 [Print] Japan
• PMID: 8309064 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cephalosporins
• S 1108

Topics

• Absorption
• Bacteria (drug effects, isolation & purification)
• Bacterial Infections (drug therapy, metabolism, microbiology)
• Cephalosporins (pharmacokinetics, therapeutic use)
• Child
• Child, Preschool
• Drug Evaluation
• Female
• Humans
• Infant
• Male