[Laboratory and clinical evaluation of S-1108 in pediatric field].

Abstract

We performed laboratory and clinical evaluation of S-1108 granules, a new oral cephalosporin antibiotic, in the pediatric field. 1. Pharmacokinetics of S-1108 was examined with 6 patients, at a dose of 4 mg/kg that was orally ingested 30 minutes after meal. Mean plasma concentrations at 30 minutes, 1, 2, 4, 6 and 8 hours after dose were 0.35, 0.63, 0.86, 0.75, 0.37 and 0.09 microgram/ml, respectively, with a half life of 1.14 hours. The urinary recovery rate in the first 8 hours was 25.5%. 2. The clinical efficacy of S-1108 was evaluated in 31 patients with various infectious diseases. S-1108 was administered at doses ranging 2 to 4.2 mg/kg/dosage, 3 times a day for 1/3 to 10 days. Clinical effects were excellent in 19, good in 12, with an efficacy rate of 100%. Bacteriologically, all causative organisms except two of Staphylococcus aureus and Haemophilus influenzae were eradicated, with an eradication rate of 80%. As an adverse reaction, mild diarrhea was noted in 2 patients. Slight elevations of GOT and/or GPT were noted in 2 patients. Only 1 child had difficulty ingesting the antibiotic preparation. From the above results, we have concluded that S-1108 is a highly effective and safe for patients with various infectious diseases in the pediatric fields.

• Authors: H Nakamura, N Iwai, M Miyazu, Y Watanabe
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 46 Issue 11 Pg. 1003-16 (Nov 1993) ISSN: 0368-2781 [Print] Japan
• PMID: 8309063 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Cephalosporins
• S 1108
• Aspartate Aminotransferases
• Alanine Transaminase

Topics

• Absorption
• Alanine Transaminase (blood)
• Aspartate Aminotransferases (blood)
• Bacteria (drug effects, isolation & purification)
• Bacterial Infections (drug therapy, metabolism, microbiology)
• Cephalosporins (adverse effects, pharmacokinetics, therapeutic use)
• Child
• Child, Preschool
• Diarrhea (chemically induced)
• Drug Evaluation
• Female
• Humans
• Infant
• Male
• Respiratory Tract Infections (drug therapy)
• Urinary Tract Infections (drug therapy)