[Intravenous dalargin as a method of increasing the effectiveness of blood reinfusion in the late stages of hemorrhagic shock].

Abstract

Acute experiments on 63 adult rabbits have shown that acute divided blood loss for 5 min (27 +/- 1% of the whole blood volume) results in the development of reversible hemorrhagic shock with survival of all the animals. In the same volume of continuous blood exfusion (27 +/- 5% of blood volume) or an increase in blood loss to 43 +/- 2% of blood volume hemorrhagic shock proved irreversible. Early reinfusion of heparinized blood saved all the animals, whereas late reinfusions only prolonged the survival. Intravenous administration of dalargin (0.1 mg/kg) in late shock was not effective and all the animals died. Dalargin introduction after blood reinfusion in late shock saved the animals lives. The conclusion is made on benefits of intravenous dalargin for raising the efficacy of reinfusions (hemotransfusion) at late stages of severe hemorrhagic shock.

• Authors: D M Sherman, V M Trach
• Journal: Gematologiia i transfuziologiia (Gematol Transfuziol) 1993 Sep-Oct Vol. 38 Issue 8 Pg. 27-30 ISSN: 0234-5730 [Print] Russia (Federation)
• Vernacular Title: Vnutrivennye vvedeniia dalargina kak metod povysheniia éffektivnosti reinfuzii krovi v pozdnem periode gemorragicheskogo shoka.
• PMID: 8307301 (Publication Type: Journal Article)

Chemical References

• Enkephalin, Leucine-2-Alanine
• enkephalin-Leu, Ala(2)-Arg(6)-

Topics

• Animals
• Blood Transfusion
• Combined Modality Therapy
• Enkephalin, Leucine-2-Alanine (administration & dosage, analogs & derivatives)
• Injections, Intravenous
• Rabbits
• Shock, Hemorrhagic (therapy)