| Abstract | This double-blind clinical trial studied 16 acutely agitated psychotic patients with manic or manic-like symptoms who needed rapid tranquilization and were therefore on maintenance treatment. They were randomized to receive intramuscular preparations of clonazepam (1 to 2 mg) or haloperidol (5 to 10 mg) at 0, 0.5, and 1.0 hours. Both medications produced significant reduction of manic symptoms within two hours of initial treatment; however, haloperidol produced beneficial results more rapidly than clonazepam. All patients completed the study, with the exception of one haloperidol-treated patient who developed severe parkinsonism. It was concluded that I.M. clonazepam is an effective, safe, but slower-acting alternative to I.M. haloperidol in the treatment of agitated psychiatric patients in need of rapid tranquilization. |
| Authors | G Chouinard, L Annable, L Turnier, N Holobow, N Szkrumelak
(Affiliation: Psychiatric Research Centre, Louis-H. Lafontaine Hospital, Montreal, Quebec.)
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| Journal | Canadian journal of psychiatry. Revue canadienne de psychiatrie
(Can J Psychiatry)
Vol. 38 Suppl 4
Pg. S114-21
(Nov 1993)
ISSN: 0706-7437 CANADA |
| PMID | 8306241
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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| Chemical References |
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| Topics |
- Adolescent
- Adult
- Arousal
(drug effects)
- Bipolar Disorder
(drug therapy, psychology)
- Clonazepam
(administration & dosage, adverse effects)
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Haloperidol
(administration & dosage, adverse effects)
- Humans
- Injections, Intramuscular
- Male
- Middle Aged
- Psychiatric Status Rating Scales
- Psychomotor Agitation
(drug therapy, psychology)
- Psychotic Disorders
(drug therapy, psychology)
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