Expression of cytochrome b558 on B cell- and CD 30 positive-lymphomas.

Expression of cytochrome b558, an essential constituent of the superoxide generating system in phagocytes, was demonstrated in B-lymphocytes. To determine its expression in malignant lymphoma (ML), 103 non-Hodgkin's MLs and 18 Hodgkin's (HD) MLs, together with non-tumorous lymphoid tissues were immunohistochemically analyzed, using two antibodies specific for the cytochrome. In non-tumorous tonsils and lymph nodes, B-lymphocytes, especially in the mantle zones, and histiocytes stained heavily, while T-lymphocytes failed to stain. Among the 55 B-MLs, all follicular lymphomas (9/9) and 18/46 of the diffuse lymphomas were found to express cytochrome b558. Among 48 T-MLs, 46 were unstained by antibodies against the cytochrome. The two cytochrome b558-positive cases were CD 30-positive anaplastic large cell lymphomas. Sixteen of 18 HD patients had CD 30-positive Reed-Sternberg cells which also stained with antibody alpha LC (an anticytochrome b558 antibody). Thus, cytochrome b558, represents a new lymphocyte differentiation antigen.
AuthorsM Shiota, S Mori, S Imajoh-Ohmi, M Nakamura, S Kanegasaki, H Serizawa, T Izumo, T Uehara
JournalPathology, research and practice (Pathol Res Pract) Vol. 189 Issue 9 Pg. 985-91 (Nov 1993) ISSN: 0344-0338 [Print] GERMANY
PMID8302731 (Publication Type: Journal Article)
Chemical References
  • Antigens, CD30
  • Cytochrome b Group
  • cytochrome b558
  • NADPH Oxidase
  • Antigens, CD30 (analysis)
  • B-Lymphocytes (chemistry)
  • Cytochrome b Group (analysis)
  • Hodgkin Disease (metabolism, pathology)
  • Humans
  • Immunohistochemistry
  • Immunophenotyping
  • Lymphoid Tissue (chemistry)
  • Lymphoma, B-Cell (chemistry, pathology)
  • Lymphoma, Non-Hodgkin (chemistry, pathology)
  • Lymphoma, T-Cell (chemistry, pathology)
  • NADPH Oxidase
  • Reed-Sternberg Cells (chemistry)
  • T-Lymphocytes (chemistry)

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