Selegiline in de novo parkinsonian patients: the Finnish study.

Abstract

Selegiline (L-deprenyl) has been recommended as an antiparkinsonian drug to be used as an adjunct to therapy with L-dopa, if and when L-dopa starts to lose its effect. However, initial selegiline monotherapy followed by L-dopa may be both effective and safe. A double-blind, placebo-controlled trial was carried out in previously untreated patients with Parkinson's disease randomized to receive selegiline (10 mg/day; 27 patients) or placebo (25 patients) until L-dopa treatment became imperative. Three rating scales were used for assessment. The study design continues to be double-blind even after L-dopa is introduced. L-Dopa was needed after 545 +/- 90 days in the selegiline group. This was significantly later (p = 0.03) than after placebo (372 +/- 28 days). Disability was less severe in the selegiline group, and there were no serious adverse effects. A nearly twofold dose of L-dopa was needed in the placebo group to achieve a sufficient therapeutic effect during long-term treatment. These results show that selegiline is safe and effective as monotherapy in early parkinsonism. It delays the need for L-dopa treatment and reduces the amount of daily L-dopa required. This could be explained by either a symptomatic effect or neuroprotective efficacy or, more likely, a combination of both.

• Authors: V V Myllylä, K A Sotaniemi, J A Vuorinen, E H Heinonen
• Journal: Movement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 8 Suppl 1 Pg. S41-4 ( 1993) ISSN: 0885-3185 [Print] United States
• PMID: 8302307 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Selegiline
• Levodopa

Topics

• Activities of Daily Living
• Aged
• Double-Blind Method
• Drug Therapy, Combination
• Female
• Finland
• Follow-Up Studies
• Humans
• Levodopa (therapeutic use)
• Male
• Middle Aged
• Neurologic Examination
• Parkinson Disease (drug therapy)
• Selegiline (therapeutic use)