[Blood levels of 6-keto-prostaglandin F1alpha, thromboxane and prostaglandin F2alpha in patients with bronchial asthma].

Abstract

The study revealed the relation of bronchial asthma (bacterial variant) clinical pattern to plasma levels of PGF2 alpha, 6-keto-PGF1 alpha and TxB2. In remission of the disease the above indices are lower. Severe asthma remission is characterized by higher levels of 6-keto-PGF1 alpha and TxB2 than moderate asthma one, demonstrates a tendency to growing PGF2 alpha levels. A rise in PGF2 alpha and TxB2 in manifest asthma points to their participation in bronchospasm formation suggesting an active role of these bronchoconstrictors in asthma pathogenesis. Higher levels of 6-keto-PGF1 alpha are of a compensary nature in the pathogenesis of PGF2 alpha and TxB2 bronchoconstrictory action, and of damaging nature contributing to the formation of bronchial mucosa edema and bronchial gland hypersecretion.

• Authors: L G Grigorian, T A Chervinskaia
• Journal: Klinicheskaia meditsina (Klin Med (Mosk)) Vol. 71 Issue 5 Pg. 24-7 ( 1993) ISSN: 0023-2149 [Print] Russia (Federation)
• Vernacular Title: Soderzhanie 6-ketoprostaglandina F1alfa, tromboksana i prostaglandina F2alfa v krovi bolńykh bronkhialńoĭ astmoĭ.
• PMID: 8301978 (Publication Type: English Abstract, Journal Article)

Chemical References

• Thromboxane A2
• 6-Ketoprostaglandin F1 alpha
• Dinoprost

Topics

• 6-Ketoprostaglandin F1 alpha (blood)
• Adolescent
• Adult
• Asthma (blood, etiology, therapy)
• Dinoprost (blood)
• Female
• Humans
• Male
• Middle Aged
• Remission Induction
• Severity of Illness Index
• Thromboxane A2 (blood)