[Effect of some drugs on the intensity of lipid peroxidation in surrounding tissues in the local treatment of suppuration].

Abstract

The effect of some drugs in their local use for treatment of purulent wounds on the intensity of peroxide oxidation of lipids in the perifocal tissues of an experimental suppurative focus was studied. The increased antioxidant and antiinflammatory effect in use of lyposomal form of gentamycin with the ectericide-modified membranes versus ectericide solution as well as more pronounced antioxidant and antiinflammatory effect of ferecterisole vs. cimesole was revealed. The results obtained indicate that the use of ferecterisole and lyposomal forms of some antibiotics for local treatment of purulent wounds has good prospects.

• Authors: B M Datsenko, I L Dikiĭ, V A Shchur, T P Bondarenko
• Journal: Klinicheskaia khirurgiia (Klin Khir (1962)) Issue 3 Pg. 34-7 ( 1993) Ukraine
• Vernacular Title: Vliianie nekotorykh preparatov na intensivnost perekisnogo okisleniia lipidov v perifokalńykh tkaniakh pri mestnom lechenii gnoĭnogo ochaga.
• PMID: 8301952 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Infective Agents
• Anti-Infective Agents, Local
• Drug Carriers
• Gentamicins
• Liposomes
• Organic Chemicals
• Tissue Extracts
• ferecterisole
• Malondialdehyde
• ectericide
• cymezol

Topics

• Animals
• Anti-Infective Agents (pharmacology, therapeutic use)
• Anti-Infective Agents, Local (pharmacology, therapeutic use)
• Burns (drug therapy, metabolism)
• Drug Carriers
• Drug Therapy, Combination
• Gentamicins (pharmacology, therapeutic use)
• Lipid Peroxidation (drug effects)
• Liposomes
• Male
• Malondialdehyde (metabolism)
• Models, Biological
• Organic Chemicals
• Random Allocation
• Rats
• Suppuration
• Tissue Extracts