| Abstract | Haemophilus capsular polysaccharide-tetanus toxoid conjugate (PRP-T) and diphtheria-tetanus-pertussis (DTP) vaccines were administered in a single syringe (group 1) or separate syringes (group 2) to 284 infants at 2, 4, and 6 months of age. Group 1 infants had a slightly greater incidence of local reactions. Systemic reactions were similar. The geometric mean titers of polyribosylribitol phosphate (PRP) serum antibody concentrations after the third dose of PRP-T vaccine were 4.8 and 4.3 micrograms/ml for groups 1 and 2, respectively. Antibody responses to DTP antigens were also similar. The immunogenicity and safety of the PRP-T and DTP vaccines are equivalent when the vaccines are administered in separate syringes or the same syringe to infants. |
| Authors | S L Kaplan, B A Lauer, M A Ward, B L Wiedermann, K M Boyer, C M Dukes, D M Schaffer, J Paisley, R Mendelson, F Pedreira
(Affiliation: Department of Pediatrics, Baylor College of Medicine, Houston, Texas.)
|
| Journal | The Journal of pediatrics
(J Pediatr)
Vol. 124
Issue 2
Pg. 323-7
(Feb 1994)
ISSN: 0022-3476 UNITED STATES |
| PMID | 8301447
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antibodies, Bacterial
- Diphtheria-Tetanus-Pertussis Vaccine
- Haemophilus Vaccines
- Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate
- Tetanus Toxoid
- Vaccines, Conjugate
|
| Topics |
- Antibodies, Bacterial
(blood)
- Diphtheria
(immunology)
- Diphtheria-Tetanus-Pertussis Vaccine
(administration & dosage, adverse effects, immunology)
- Drug Therapy, Combination
- Haemophilus Vaccines
(administration & dosage, adverse effects, immunology)
- Haemophilus influenzae
(immunology)
- Humans
- Infant
- Tetanus
(immunology)
- Tetanus Toxoid
(administration & dosage, adverse effects, immunology)
- Vaccines, Conjugate
(administration & dosage, adverse effects, immunology)
- Whooping Cough
(immunology)
|
