Immunostimulant activity of a novel lipopeptide and its protective action against Leishmania donovani.

Abstract

Novel lipopeptides 84/201 and 86/450 synthesized in this laboratory stimulated antibody and delayed type hypersensitivity (DTH) response to ovalbumin in guinea pigs. Lipopeptide 86/450 also stimulated antibody and DTH responses in albino mice and enhanced nonspecifically macrophage migration index (MMI), phagocytic activity and incorporation of [14C] glucosamine in peritoneal macrophages of the treated animals. Proliferative response of splenocytes from lipopeptide 86/450 treated animals was significantly higher than that from untreated controls. Peritoneal macrophages from lipopeptide 86/450 treated mice were less susceptible to Leishmania donovani promastigote invasion when co-cultured in vitro. The treated animals on challenge with L. donovani promastigote/amastigote showed 80 to 90% lower intake of infection than the control animals.

• Authors: A Puri, S Y Rizvi, W Haq, P Y Guru, B Kundu, R P Saxena, R Shukla, K B Mathur, K C Saxena
• Journal: Immunopharmacology and immunotoxicology (Immunopharmacol Immunotoxicol) Vol. 15 Issue 5 Pg. 539-56 (Nov 1993) ISSN: 0892-3973 [Print] England
• PMID: 8301018 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Lipopeptides
• Lipoproteins
• lipopeptide 84-201
• lipopeptide 86-450
• Ovalbumin

Topics

• Adjuvants, Immunologic (chemistry, pharmacology)
• Amino Acid Sequence
• Animals
• Antibody Formation (drug effects)
• Cell Movement (drug effects)
• Cricetinae
• Female
• Guinea Pigs
• Hypersensitivity, Delayed
• In Vitro Techniques
• Leishmania donovani (immunology)
• Leishmaniasis, Visceral (prevention & control)
• Lipopeptides
• Lipoproteins (chemistry, pharmacology)
• Lymphocyte Activation (drug effects)
• Macrophages, Peritoneal (drug effects, immunology, parasitology)
• Male
• Mesocricetus
• Mice
• Mice, Inbred BALB C
• Molecular Sequence Data
• Ovalbumin (immunology)
• Phagocytosis (drug effects)