Norepinephrine transporter sites are decreased in the locus coeruleus in Alzheimer's disease.

Abstract	The present study determined whether [3H]nisoxetine binding to norepinephrine transporter sites would be altered uniformly throughout the locus coeruleus in Alzheimer's disease. A significant decrease (P < 0.01) in [3H]nisoxetine binding was seen in the mid and caudal regions but not in the rostral region of the locus coeruleus. The loss of [3H]nisoxetine binding to norepinephrine transporter sites may be attributed to a loss of norepinephrine transporter sites located on terminals of noradrenergic neurons in the locus coeruleus in Alzheimer's disease.
Authors	S M Tejani-Butt, J Yang, H Zaffar
Journal	Brain research (Brain Res) Vol. 631 Issue 1 Pg. 147-50 (Dec 17 1993) ISSN: 0006-8993 [Print] Netherlands
PMID	8298987 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Carrier Proteins Norepinephrine Plasma Membrane Transport Proteins SLC6A2 protein, human Symporters Fluoxetine nisoxetine Norepinephrine
Topics	Aged Aged, 80 and over Alzheimer Disease (metabolism) Autoradiography Carrier Proteins (metabolism) Female Fluoxetine (analogs & derivatives, metabolism) Humans Locus Coeruleus (metabolism) Male Middle Aged Norepinephrine (antagonists & inhibitors, metabolism) Norepinephrine Plasma Membrane Transport Proteins Symporters Tissue Distribution

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!