[The use of immunoregulator preparations in the combined treatment of idiopathic hypothyroidism].

Abstract

A comparative analysis of idiopathic hypothyroidism (IHT) outcomes in different therapeutic regimens which incorporated or did not incorporate splenin and sodium nucleinate showed more frequent disease exacerbations in patients who received no immunoactive drugs. Combined therapy reduced the number of patients with decompensation 3.7-fold. Stable IHT compensation was achieved in those patients who had received adjuvant splenin in 80.8% of cases, sodium nucleinate in 86.2% against a 40.9% response rate under conventional replacement therapy with thyreoidin.

• Authors: A V Epishin, N A Khabarova, V E Grytsiv, E P Venger
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 65 Issue 10 Pg. 39-42 ( 1993) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Primenenie immunoreguliruiushchikh preparatov v kompleksnom lechenii idiopaticheskogo gipotireoza.
• PMID: 8296231 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Immunoglobulins

Topics

• Adjuvants, Immunologic (therapeutic use)
• Adult
• B-Lymphocytes (drug effects, immunology)
• Chronic Disease
• Drug Evaluation
• Drug Therapy, Combination
• Female
• Humans
• Hypothyroidism (diagnosis, drug therapy, immunology)
• Immunoglobulins (analysis, drug effects)
• Male
• Middle Aged
• T-Lymphocytes (drug effects, immunology)