Abstract |
Adrenalectomized female rats with lesions of the ventromedial hypothalamus or sham lesions were given SC implants of wax pellets or a fused mixture of corticosterone- cholesterol (40, 75, or 130% by weight). In animals with sham lesions, high dosages of corticosterone proved to be catabolic (r = -0.61 between plasma corticosterone and weight change). In marked contrast, animals with VMH lesions displayed substantial weight gains at all circulating levels of corticosterone, with a significant positive correlation (r = +0.48) between these two variables. It is concluded that: a) damage to the basomedial hypothalamus alters an organism's response to corticosterone at both ends of the dose-response curve, and b) both Type I and Type II corticosterone receptors in the brain play a role in hypothalamic obesity.
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Authors | B M King, C A Zansler, A C Tatford 3rd, K L Neville, H Sam, J M Kass, M F Dallman |
Journal | Physiology & behavior
(Physiol Behav)
Vol. 54
Issue 6
Pg. 1187-90
(Dec 1993)
ISSN: 0031-9384 [Print] United States |
PMID | 8295962
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Blood Glucose
- Insulin
- Receptors, Steroid
- corticosterone receptor
- Adrenocorticotropic Hormone
- Corticosterone
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Topics |
- Adrenal Glands
(physiology)
- Adrenalectomy
- Adrenocorticotropic Hormone
(blood)
- Animals
- Blood Glucose
(metabolism)
- Brain Mapping
- Corticosterone
(administration & dosage, blood)
- Eating
(physiology)
- Female
- Insulin
(blood)
- Rats
- Receptors, Steroid
(drug effects, physiology)
- Ventromedial Hypothalamic Nucleus
(drug effects, physiology)
- Weight Gain
(drug effects, physiology)
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