A new antitumor substance, BE-18591, produced by a streptomycete. I. Fermentation, isolation, physico-chemical and biological properties.

Abstract	New antitumor substance, designated BE-18591, was isolated from the culture broth of a streptomycete, strain BA18591. The active principle was extracted from mycelium by methanol and purified by silica gel chromatography. BE-18591 inhibited the growth of MKN-45 human stomach cancer cell line as well as P388 cell line. In in vivo experiments, BE-18591 inhibited the growth of Ehrlich ascites tumor.BE-18591 showed antimicrobial activity against Gram-positive and some Gram-negative bacteria.
Authors	K Kojiri, S Nakajima, H Suzuki, A Okura, H Suda
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 46 Issue 12 Pg. 1799-803 (Dec 1993) ISSN: 0021-8820 [Print] England
PMID	8294236 (Publication Type: Journal Article)
Chemical References	Antibiotics, Antineoplastic Pyrroles BE 18591
Topics	Animals Antibiotics, Antineoplastic (isolation & purification, metabolism, pharmacology) Cell Division (drug effects) Chemical Phenomena Chemistry, Physical Fermentation Leukemia P388 (drug therapy, pathology) Magnetic Resonance Spectroscopy Mice Pyrroles (isolation & purification, metabolism, pharmacology) Streptomyces (chemistry, metabolism)

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