Pregnancy specific beta 1 glycoprotein (SP-1) in maternal serum and amniotic fluid; pre-eclampsia, small for gestational age fetus and fetal distress.

Abstract

Pregnancy specific beta 1 glycoprotein (SP-1) levels have been suggested to correlate with certain obstetrical complications. We compared maternal serum SP-1 levels in normal pregnancies (N = 82), and pregnancies complicated by pre-eclampsia (N = 37), small for gestational age fetuses (N = 8) and fetal distress (N = 13). We also compared levels of this protein in mid-trimester amniotic fluid samples obtained from normal (N = 47) and small for gestational age fetuses (N = 25). Despite trends towards low maternal serum and amniotic fluid SP-1 values in complicated pregnancies, there were no statistically significant differences in their levels as compared with normal gestational age matched controls (P > 0.05). These data do not support the use of SP-1 values in clinical practice.

• Authors: R M Silver, K D Heyborne, K K Leslie
• Journal: Placenta (Placenta) 1993 Sep-Oct Vol. 14 Issue 5 Pg. 583-9 ISSN: 0143-4004 [Print] Netherlands
• PMID: 8290497 (Publication Type: Journal Article)

Chemical References

• Pregnancy-Specific beta 1-Glycoproteins

Topics

• Adult
• Amniotic Fluid (metabolism)
• Female
• Fetal Distress (metabolism)
• Gestational Age
• Humans
• Infant, Newborn
• Infant, Small for Gestational Age (metabolism)
• Pre-Eclampsia (metabolism)
• Pregnancy (blood, metabolism)
• Pregnancy-Specific beta 1-Glycoproteins (metabolism)
• Radioimmunoassay
• Reference Values