[Comparative clinical study of Neopanpur and Creon].

Abstract

The aim of the study was to compare the clinical efficacy of Neopanpur (EGIS) and Creon (Kalichemie) in patients with chronic pancreatitis. Fifteen patients were examined for 2 x 10 days. A period: Neopanpur 3 x 2, B period: Creon 10,000 3 x 2. The type of the trial was: randomized, open, crossover study. The complaints of the patients (in score), the characters of the stool (daily weight, fat content, foamy, smell), amylum tolerance test (ATT), H2-breath test, lipjodol-test, Lundh-test and Schilling-test were determined before and during the treatment periods. Both enzyme preparations could effectively decrease the anamnestic complaints, the stool frequency and characteristics together with the laboratory results of pancreatic functions. There is no clinically significant difference between the clinical efficacy of Creon and Neopanpur. Both enzyme preparations can be applied in the treatment of maldigestion in patients with chronic pancreatic insufficiency.

• Authors: T Beró, T Jávor
• Journal: Orvosi hetilap (Orv Hetil) Vol. 135 Issue 1 Pg. 7-14 (Jan 02 1994) ISSN: 0030-6002 [Print] Hungary
• Vernacular Title: Neopanpur és Kreon összehasonlító klinikai vizsgálata.
• PMID: 8290236 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Neopanpur
• Pancreatic Extracts
• Pancrelipase
• Lipase

Topics

• Adult
• Chronic Disease
• Drug Evaluation
• Female
• Humans
• Lipase (therapeutic use)
• Male
• Middle Aged
• Pancreatic Extracts (therapeutic use)
• Pancreatitis (drug therapy)
• Pancrelipase