Sumatriptan blocks neurogenic inflammation in the peripheral nerve trunk.

Abstract

We tested the action of intraperitoneal sumatriptan, a 5-HT1D receptor agonist that aborts migraine headaches, using a model of neurogenic inflammation induced by capsaicin applied to the rat sciatic epineurium. Sumatriptan prevented the development of capsaicin-induced hyperemia without inducing pretreatment vasoconstriction or altering AV shunt flow. The findings indicate that sumatriptan prevents "neurogenic" vasodilation by a mechanism other than vasoconstriction or changes in AV shunt flow.

• Authors: D W Zochodne, L T Ho
• Journal: Neurology (Neurology) Vol. 44 Issue 1 Pg. 161-3 (Jan 1994) ISSN: 0028-3878 [Print] United States
• PMID: 8290056 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Sumatriptan
• Capsaicin

Topics

• Animals
• Capsaicin (antagonists & inhibitors)
• Hyperemia (chemically induced)
• Male
• Microcirculation (drug effects)
• Neuritis (chemically induced, pathology)
• Rats
• Rats, Sprague-Dawley
• Regional Blood Flow (drug effects)
• Sciatic Nerve (blood supply)
• Sumatriptan (pharmacology)
• Vascular Resistance (drug effects)