Photohemolytic activity of lichen metabolites.

Abstract

Irradiation of pannarin 1'-chloropannarin and antranorin with 366 nm light leads to significant hemolysis in a red cell suspension. However, their mechanism of action is different. Hemolysis induced by pannarin and 1'chloropannarin increases in the presence of oxygen, whereas hemolysis induced by atranorin is higher in nitrogen-purged solutions. The effect of free radical scavengers, and the lack of effect of D2O in the medium, suggest that the hemolysis induced by pannarin and 1'chloropannarin is not mediated by (1)O2. Both the hemolytic and photohemolytic activities of the depsidones, particularly 1'-chloropannarin, increase when the temperature increases from 21 to 37 degrees C.

• Authors: M E Hidalgo, E Fernández, W Quilhot, E A Lissi
• Journal: Journal of photochemistry and photobiology. B, Biology (J Photochem Photobiol B) Vol. 21 Issue 1 Pg. 37-40 (Nov 1993) ISSN: 1011-1344 [Print] Switzerland
• PMID: 8289110 (Publication Type: Journal Article)

Chemical References

• Allergens
• Antifungal Agents
• Benzoxepins
• Depsides
• Free Radical Scavengers
• Hydroxybenzoates
• atranorin
• argopsin
• pannarin

Topics

• Adult
• Allergens
• Antifungal Agents (radiation effects)
• Benzoxepins (pharmacology, radiation effects)
• Darkness
• Depsides
• Free Radical Scavengers
• Hemolysis (drug effects, radiation effects)
• Humans
• Hydroxybenzoates (pharmacology, radiation effects)
• In Vitro Techniques
• Lichens
• Ultraviolet Rays