[The pharmacodynamics of troxipide on experimental gastric ulcers in rats].

Abstract

Effects of troxipide (Ku-54) on various experimental gastric ulcers in rats were studied. Ku-54 showed a dose-dependent antiulcerous action at 100, 200 and 300 mg/kg (particularly 300 mg/kg) p.o. in water-immersion stress, pylorus ligated and acetic acid reduced rats. The effect of cimetidine (CIM) (600 mg/kg) on water-immersion stress rats was significantly higher than that of Ku-54(300 mg/kg). On the other hand, the effect of Ku-54 (300 mg/kg) was higher than that of CIM (600 mg/kg) on the pylorus ligated and acetic acid reduced groups. The antiulcerous action of Ku-54 (300 mg/kg) was not related with the content and the pH of gastric juice.

• Authors: J Wang, L Zhang, Z Fang, A Fan, Y Wang
• Journal: Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao (Hua Xi Yi Ke Da Xue Xue Bao) Vol. 24 Issue 3 Pg. 313-6 (Sep 1993) ISSN: 0257-7712 [Print] China
• PMID: 8288208 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Acetates
• Anti-Ulcer Agents
• Piperidines
• Cimetidine
• Acetic Acid
• troxipide

Topics

• Acetates
• Acetic Acid
• Animals
• Anti-Ulcer Agents (pharmacology, therapeutic use)
• Cimetidine (therapeutic use)
• Female
• Male
• Piperidines (pharmacology, therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Stomach Ulcer (drug therapy, etiology)
• Stress, Physiological