Comparison of plasma pancreastatin and GAWK concentrations, presumed processing products of chromogranin A and B, in plasma of patients with pancreatic islet cell tumors.

Abstract

Plasma pancreastatin (PST) and GAWK, peptides processed from chromogranin A and B, were elevated in patients with various neuroendocrine tumors. In the present study, we measured plasma PST- and GAWK-like immunoreactivity (LI) concentrations in 12 patients with pancreatic islet cell tumors and evaluated them as a marker for these tumors. We also performed the gel filtration of the plasma from a gastrinoma patient and investigated the processing of PST and GAWK in plasma. Elevation of plasma PST-LI was found in 4 of 12 patients (33%) and elevation of plasma GAWK-LI was found in 6 of 12 patients (50%). A significant correlation was not found between plasma PST- and GAWK-LI concentrations of the patients. In the gel permeation chromatography of the plasma from a gastrinoma patient, PST-LI composed of a single peak but GAWK-LI composed of several components with wide range molecular weights.

• Authors: D Yasuda, H Iguchi, A Funakoshi, H Wakasugi, K Sekiya, T Misawa, K Tateishi, S R Bloom, H Nawata
• Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (Horm Metab Res) Vol. 25 Issue 11 Pg. 593-5 (Nov 1993) ISSN: 0018-5043 [Print] Germany
• PMID: 8288164 (Publication Type: Journal Article)

Chemical References

• CHGA protein, human
• Chromogranin A
• Chromogranin B
• Chromogranins
• Nerve Tissue Proteins
• Pancreatic Hormones
• pancreastatin
• GAWK

Topics

• Adenoma, Islet Cell (blood)
• Amino Acid Sequence
• Chromatography, Gel
• Chromogranin A
• Chromogranin B
• Chromogranins (metabolism)
• Gastrinoma (blood)
• Humans
• Molecular Sequence Data
• Molecular Weight
• Nerve Tissue Proteins (blood)
• Pancreatic Hormones (blood)
• Pancreatic Neoplasms (blood)