Role of 5-hydroxytryptamine in the progression of monocrotaline induced pulmonary hypertension in rats.

Abstract

OBJECTIVE:

The aim was to clarify the role of serotonin (5-hydroxytryptamine, 5-HT) in monocrotaline induced pulmonary hypertension.

METHODS:

Plasma 5-HT levels, pulmonary capillary platelet count, and vascular responsiveness to 5-HT were evaluated in the model. The effects of the selective 5-HT2 receptor antagonist, DV-7028, on the development of pulmonary hypertension were also investigated.

RESULTS:

Plasma 5-HT was raised 12 h to 3 d after monocrotaline administration (60 mg.kg-1), coinciding with accumulation of platelets in the pulmonary circulation. Isolated pulmonary arteries showed hyperreactivity to 5-HT at 14 and 21 d after monocrotaline. Administration of DV-7028 (20 mg.kg-1 x d-1) attenuated the increase in pulmonary arterial pressure, right ventricular hypertrophy, and medial thickening of the pulmonary arteries.

CONCLUSIONS:

The present study suggests that 5-HT released from platelets contributes to the initiation and progression of monocrotaline induced pulmonary hypertension.

• Authors: Y Kanai, S Hori, T Tanaka, M Yasuoka, K Watanabe, N Aikawa, Y Hosoda
• Journal: Cardiovascular research (Cardiovasc Res) Vol. 27 Issue 9 Pg. 1619-23 (Sep 1993) ISSN: 0008-6363 [Print] England
• PMID: 8287439 (Publication Type: Journal Article)

Chemical References

• Piperidines
• Serotonin Antagonists
• Triazines
• DV 7028
• Serotonin
• Monocrotaline

Topics

• Animals
• Blood Platelets (ultrastructure)
• Culture Techniques
• Hypertension, Pulmonary (blood, chemically induced, pathology)
• Lung (ultrastructure)
• Male
• Monocrotaline (toxicity)
• Piperidines (pharmacology)
• Platelet Count
• Pulmonary Artery (drug effects)
• Rats
• Serotonin (blood, pharmacology, physiology)
• Serotonin Antagonists (pharmacology)
• Triazines (pharmacology)