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Cytomegalovirus polyradiculopathy caused by a ganciclovir-resistant strain.

Abstract
Polyradiculopathy caused by cytomegalovirus (CMV) is a rare but serious neurological disorder that occurs late in the course of HIV-1 infection and is potentially treatable with antimicrobial agents active against CMV. We describe a patient with CMV infection caused by a strain that was resistant to ganciclovir. This case demonstrates one potential mechanism of therapeutic failure and illustrates the potential pathogenicity of strains that are resistant to antiviral drugs.
AuthorsJ I Tokumoto, H Hollander
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 17 Issue 5 Pg. 854-6 (Nov 1993) ISSN: 1058-4838 [Print] United States
PMID8286625 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Ganciclovir
Topics
  • AIDS-Related Opportunistic Infections (complications, drug therapy, microbiology)
  • Adult
  • Cytomegalovirus (drug effects)
  • Cytomegalovirus Infections (complications, drug therapy, microbiology)
  • Cytomegalovirus Retinitis (complications, drug therapy)
  • Drug Resistance, Microbial
  • Ganciclovir (therapeutic use)
  • HIV-1
  • Humans
  • Male
  • Polyradiculopathy (complications, drug therapy, microbiology)

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