[The use of saliva for study in the immunoenzyme analysis of postvaccinal and postinfectious immunity to influenza].

Abstract

Paired specimens of blood sera, upper respiratory tract secretions, and saliva from healthy, influenza-infected, and live influenza trivaccine-immunized humans were tested in parallel by HI tests and enzyme immunoassay (EIA). The resulting comparative data suggest that determination by EIA of specific secretory IgA in the saliva may be recommended as an independent test for large-scale influenza diagnosis, evaluation of the immune status of people, and trials of influenza vaccines. By immunologic parameters, this method is not inferior to the standard ones. At the same time its advantages include simplicity and readily available large volumes of saliva even from children as well as no necessity to bleed subjects to be examined.

• Authors: A N Naĭkhin, A A Mikhaĭlov, Iu G Kustikova, L M Tsybalova, V B Klimovich, S A Artem'eva, A I Krasheniuk, L G Katorgina, T N Kim, G M Denisov
• Journal: Voprosy virusologii (Vopr Virusol) 1993 Sep-Dec Vol. 38 Issue 5 Pg. 201-4 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Ispol'zovanie sliuny dlia izucheniia v immunofermentnom analize postvaktsinal'nogo i postinfektsionnogo immuniteta k grippu.
• PMID: 8284915 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antibodies, Viral
• Immunoglobulin A, Secretory
• Influenza Vaccines

Topics

• Adult
• Antibodies, Viral (analysis)
• Antibody Specificity
• Hemagglutination Inhibition Tests
• Humans
• Immunization
• Immunoenzyme Techniques
• Immunoglobulin A, Secretory (analysis)
• Influenza A virus (immunology)
• Influenza Vaccines (immunology)
• Influenza, Human (diagnosis, immunology, prevention & control)
• Military Personnel
• Russia
• Saliva (immunology)